Biomarkers of Esophageal Cancer Comes of Age?
نویسنده
چکیده
Despite improvements in surgical techniques, adjuvant chemotherapy and radiotherapy, many patients with esophageal carcinoma still suffer rapid recurrence of the disease and a poor prognosis [1]. Biomarkers should be useful tools to evaluate biological features of esophageal carcinoma to predict recurrence and/or patients’ survival [2]. Basically, thoracic esophageal squamous cell carcinoma (SCC) has very similar biological character to head & neck SCC. Moreover, thoracic esophageal adenocarcinoma has very similar to esophago-gastric junction adenocarcinoma. Based on development of various companion biomarkers for molecular targeting agents for head & neck SCC and/or gastric adenocarcinoma, potential biomarkers, recently, have been reported for esophageal cancer [3-6].
منابع مشابه
Comparative proteome analysis of human esophageal cancer and adjacent normal tissues
Objective(s): Ranking as the sixth commonest cancer, esophageal squamous cell carcinoma (ESCC) represents one of the leading causes of cancer death worldwide. One of the main reasons for the low survival of patients with esophageal cancer is its late diagnosis. Materials and Methods: We used proteomics approach to analyze ESCC tissues with the aim of a better understanding of the malignant mech...
متن کاملThe Prognostic Value of Serine and Glycine Levels in Plasma in Patients with Esophageal Cancer: A Case Control Study
Background and Objective: Serine and glycine are connecting lines for biosynthesis and are essential resources for synthesis of proteins, nucleic acids and lipids that are necessary for cancer cell growth. The purpose of this study was to set a comparison of serine and glycine in patients with esophageal cancer and in healthy people. Materials and Methods: 37 plasma samples were collected from...
متن کاملInvestigating the role of signaling pathways and cancer stem cells in esophageal cancer with a therapeutic approach
Esophageal cancer (EC) is the sixth main cause of cancer death worldwide. Important genes associated with esophageal cancer include FOXO3, AKT, and GSK3β. Excessive FOXO3 expression inhibits the proliferation of cancer cells. The expression of AKT is involved in controlling cell growth in tumors. GSK3β activity is higher in cancer tissues. Given the effective role of cancer stem cells (CSCs) in...
متن کاملAnalyzing the Expression Level and Associated Clinical Characteristics of miRNA-138 in Esophageal Squamous Cell Carcinoma in Iranian Patients
Background: Esophageal Squamous Cell Carcinoma (ESCC) is the seventh most common and lethal malignancy worldwide with a high incidence in Iran. Esophageal cancer has a poor prognosis and low 5-years survival rate. Despite several studies on esophageal cancer, its underlying mechanism remains unclear. Therefore, it is significant to analyze the molecular factors involved in disease for introduci...
متن کاملAclinicopathological survey of esophageal cancer in patients referred to a gastroenterology clinic in Tehran, 1991-2005
Abstract Background: Esophageal cancer is one of the major malignancies, with various epidemiological aspects in recent years in developing countries, including increased prevalence and variations of pathologic patterns. This may be due to increasing rates of Barrett’s esophagus, gastroesophageal reflux, smoking and obesity. This study was performed from 1991 to 2005 in order to evaluate vario...
متن کامل